AML Evolution: Primary to Relapsed AML

Fish plots are designed to visualize tumor evolution. This visualizationwas inspired by the fishplot package for R by Christopher A. Miller, Joshua McMichael, Ha X. Dang, Christopher A. Maher, Li Ding, Timothy J. Ley, Elaine R. Mardis & Richard K. Wilson

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<html>

  <head>
    <!-- Include the CanvasXpress library in your HTML file -->
    <link rel="stylesheet" href="https://www.canvasxpress.org/dist/canvasXpress.css" type="text/css"/>
    <script src="https://www.canvasxpress.org/dist/canvasXpress.min.js"></script>
  </head>

  <body>

    <!-- Create a canvas element for the chart with the desired dimensions -->
    <div>
      <canvas id="canvasId" width="600" height="600"></canvas>
    </div>


    <!-- Create a script to initialize the chart -->
    <script>

      // Use a data frame (2D-array) for the graph
      var data = [
        [ "Id", "C1", "C2", "C3", "C4"],
        [ 0, 100, 38, 24, 0],
        [ 30, 2, 0, 1, 0],
        [ 200, 2, 0, 1, 1],
        [ 423, 100, 0, 98, 30 ]
      ];

      // Create the configuration for the graph
      var config = {
         "backgroundType" : "panelSolidGradient",
         "colorSpectrum" : ["bisque","darkgoldenrod1","darkorange3"],
         "colors" : ["rgb(136,136,136)","rgb(239,0,0)","rgb(255,96,0)","rgb(255,207,0)","rgb(191,255,64)","rgb(80,255,175)","rgb(0,223,255)","rgb(0,112,255)","rgb(0,0,255)","rgb(0,0,143)"],
         "fishAxis" : [0,423],
         "fishCloneLabels" : ["DNMT3A,FLT3","NPM1","MET","ETV6,WNK1-WAC,\\nMYO18B"],
         "fishParents" : [0,1,1,3],
         "fishShape" : "spline",
         "fishTimepoints" : [0,30,200,423],
         "gradientOrientation" : "horizontal",
         "graphType" : "Fish",
         "legendKeyBackgroundBorderColor" : "rgba(255,255,255,0)",
         "legendKeyBackgroundColor" : "rgba(255,255,255,0)",
         "varTextColor" : "green",
         "varTextRotate" : 30,
         "xAxis" : ["C1","C2","C3","C4"]
      }

      // Event used to create graph (optional)
      var events = false


      // Call the CanvasXpress function to create the graph
      var cX = new CanvasXpress("canvasId", data, config, events);

      
    </script>

  </body>

</html>

<html>

  <head>
    <!-- Include the CanvasXpress library in your HTML file -->
    <link rel="stylesheet" href="https://www.canvasxpress.org/dist/canvasXpress.css" type="text/css"/>
    <script src="https://www.canvasxpress.org/dist/canvasXpress.min.js"></script>
  </head>

  <body>

    <!-- Create a canvas element for the chart with the desired dimensions -->
    <div>
      <canvas id="canvasId" width="600" height="600"></canvas>
    </div>


    <!-- Create a script to initialize the chart -->
    <script>

      // Create the data for the graph
      var data = {
         "y" : {
            "data" : [
              [100,2,2,100],
              [38,0,0,0],
              [24,1,1,98],
              [0,0,1,30]
            ],
            "smps" : [0,30,200,423],
            "vars" : ["C1","C2","C3","C4"]
         }
      }

      // Create the configuration for the graph
      var config = {
         "backgroundType" : "panelSolidGradient",
         "colorSpectrum" : ["bisque","darkgoldenrod1","darkorange3"],
         "colors" : ["rgb(136,136,136)","rgb(239,0,0)","rgb(255,96,0)","rgb(255,207,0)","rgb(191,255,64)","rgb(80,255,175)","rgb(0,223,255)","rgb(0,112,255)","rgb(0,0,255)","rgb(0,0,143)"],
         "fishAxis" : [0,423],
         "fishCloneLabels" : ["DNMT3A,FLT3","NPM1","MET","ETV6,WNK1-WAC,\\nMYO18B"],
         "fishParents" : [0,1,1,3],
         "fishShape" : "spline",
         "fishTimepoints" : [0,30,200,423],
         "gradientOrientation" : "horizontal",
         "graphType" : "Fish",
         "legendKeyBackgroundBorderColor" : "rgba(255,255,255,0)",
         "legendKeyBackgroundColor" : "rgba(255,255,255,0)",
         "varTextColor" : "green",
         "varTextRotate" : 30,
         "xAxis" : ["C1","C2","C3","C4"]
      }

      // Event used to create graph (optional)
      var events = false


      // Call the CanvasXpress function to create the graph
      var cX = new CanvasXpress("canvasId", data, config, events);

      
    </script>

  </body>

</html>

library(canvasXpress)
y=read.table("https://www.canvasxpress.org/data/r/cX-fish2-dat.txt", header=TRUE, sep="\t", quote="", row.names=1, fill=TRUE, check.names=FALSE, stringsAsFactors=FALSE)
canvasXpress(
  data=y,
  backgroundType="panelSolidGradient",
  colorSpectrum=list("bisque", "darkgoldenrod1", "darkorange3"),
  colors=list("rgb(136,136,136)", "rgb(239,0,0)", "rgb(255,96,0)", "rgb(255,207,0)", "rgb(191,255,64)", "rgb(80,255,175)", "rgb(0,223,255)", "rgb(0,112,255)", "rgb(0,0,255)", "rgb(0,0,143)"),
  fishAxis=list(0, 423),
  fishCloneLabels=list("DNMT3A,FLT3", "NPM1", "MET", "ETV6,WNK1-WAC,\nMYO18B"),
  fishParents=list(0, 1, 1, 3),
  fishShape="spline",
  fishTimepoints=list(0, 30, 200, 423),
  gradientOrientation="horizontal",
  graphType="Fish",
  legendKeyBackgroundBorderColor="rgba(255,255,255,0)",
  legendKeyBackgroundColor="rgba(255,255,255,0)",
  varTextColor="green",
  varTextRotate=30,
  xAxis=list("C1", "C2", "C3", "C4")
)